THE BASICS
Three things people mean by “low cortisol.”
The phrase “low cortisol” travels as widely as “high cortisol,” and it hides the same three meanings.
A feeling. Persistent tiredness is one of the most common complaints there is. Feeling drained does not show that cortisol is low.
A lab result. A single low number, taken at an unplanned time, does not answer the clinical question. Interpretation depends on timing, method and context.
A medical condition. Adrenal insufficiency is a recognized condition in which the body does not make enough cortisol. It requires a medical evaluation and, when confirmed, treatment from a clinician.
What adrenal insufficiency is
Adrenal insufficiency has more than one form. In primary adrenal insufficiency, including Addison’s disease, the adrenal glands themselves are damaged, often by an autoimmune process. In secondary adrenal insufficiency, the pituitary gland does not send enough of the signal (ACTH) that tells the adrenal glands to make cortisol. A third situation happens after long-term use of glucocorticoid medicines: stopping them suddenly can leave the body without enough cortisol for a time.
Symptoms can include lasting fatigue, weakness, weight loss, poor appetite, nausea, low blood pressure, dizziness when standing, and craving for salt. Many of these overlap with ordinary, common problems, which is why they deserve assessment instead of a guess.
Where “adrenal fatigue” fits
“Adrenal fatigue” is a popular online label for tiredness and other symptoms blamed on adrenal glands that are supposedly worn out by stress. The Endocrine Society reports no scientific evidence that it exists as a medical condition. Your symptoms are real, and they deserve attention. The risk of the label is that it can stop the search for the actual cause, and that tests and supplements marketed for it are not scientifically established.
Why this page treats symptoms seriously
We do not dismiss tiredness, and we do not accept a diagnosis from a feed. The useful question is not “is my cortisol low?” but “what could explain how I feel, and who can check?”
Do not wait with an emergency
An adrenal crisis is life-threatening. Severe weakness, confusion, repeated vomiting or diarrhea, fainting or very low blood pressure in someone who has adrenal insufficiency, or who has stopped long-term glucocorticoid medicine, needs emergency care. In the United States, call 911. If you have a diagnosed condition, follow your clinician’s emergency plan.
If you are worried
Bring a list of symptoms, when they began and any medicines you take or recently stopped. Ask whether a test is appropriate and which one. Do not start or stop a medicine, and do not buy an “adrenal support” supplement, based on a social media post.